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#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

M-TriLYS - NOD2 Agonist

Synthetic muramyl tripeptide

M-TriLYS dose-dependent activation of NOD2

#TLR7/8 Ligands

TL8-506 - TLR8 Agonist

Benzo-azepine analog - CAS #1268163-15-0

NF-κB response of HEK-Blue™-derived cells to TL8-506

NF-κB and IRF responses of THP1-Dual™-derived cells to TL8-506

PGN-SAndi ultrapure peptidoglycan - NOD2 Agonist

Insoluble peptidoglycan from S. aureus

Dose-dependent NF-κB response to PGN-SAndi Ultrapure in HEK-Blue™ hNOD2 cells

PGN-ECndss ultrapure peptidoglycan - NOD1/NOD2 Agonist

Soluble sonicated peptidoglycan from E. coli K12

Dose-dependent NF-κB response of PGN-ECndss Ultrapure in HEK-Blue™ hNOD1 and HEK-Blue™ hNOD2 cells

PGN-ECndi Ultrapure Peptidoglycan - NOD2 Agonist

Insoluble peptidoglycan from E. coli K12

Dose-dependent NF-κB response to PGN-ECndi Ultrapure in HEK-Blue™ hNOD1 and HEK-Blue™ hNOD2 cells

M-TriDAP - NOD1/NOD2 Agonist

MurNAc-L-Ala-gamma-D-Glu-mDAP - PGN-like molecule

NF-κB responses of HEK-Blue™ hNOD1 cells to various PRR agonists and cytokines

NF-kB response of HEK-Blue™ hNOD2 cells to various PRR agonists and cytokines

Murabutide - NOD2 Agonist

Synthetic derivative of muramyldipeptide

Murabutide dose-dependent activation of NOD2

N-Glycolyl-MDP - NOD2 Agonist

N-glycolylated muramyldipeptide

N-Glycolyl-MDP dose-dependent activation of NOD2

L18-MDP - NOD2 Agonist

Muramyldipeptide with a C18 fatty acid chain

L18-MDP dose-dependent activation of NOD2

MDP Control - NOD2 Agonist Negative Control

Negative control for MDP - Muramyldipeptide (L-L isomer, inactive)

Dose-dependent NF-κB response in HEK-Blue™ hNOD2 cells

MDP - NOD2 Agonist

Muramyl dipeptide (L-D isomer)

MDP dose-dependent activation of NOD2

Tri-DAP - NOD1 Agonist

L-Ala-gamma-D-Glu-mDAP

Tri-DAP dose-dependent activation of NOD1

C12-iE-DAP - NOD1 Agonist

Acylated derivative of iE-DAP

C12-iE-DAP dose-dependent activation of NOD1

iE-DAP - NOD1 Agonist

D-gamma-Glu-mDAP

Dose-dependent NF-κB responses of HEK-Blue™ hNOD1 cells to NOD1-specific ligands

#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

#TLR7/8 Ligands

ORN06/LyoVec™ - TLR7/8 Agonist

UUGU ssRNA polymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ORN06/LyoVec™

#TLR7/8 Ligands

Loxoribine - TLR7 Agonist

Guanosine analog - CAS #121288-39-9

NF-κB response of HEK-Blue™-derived cells to loxoribine

#TLR7/8 Ligands

Imiquimod (R837) - TLR7 Agonist

Imidazoquinoline compound - CAS #99011-78-6

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

#TLR7/8 Ligands

Gardiquimod™ - TLR7 Agonist

Imidazoquinoline compound - CAS #1020412-43-4

NF-κB response of HEK-Blue™-derived cells to Gardiquimod™

NF-κB and IRF responses of THP1-Dual™-derived cells to Gardiquimod™