InvivoGen provides monoclonal antibodies targeting human and murine C-type Lectin receptors (Dectin-1, Dectin-2 and Mincle) for neutralization and detection.
Dectin-1 plays an important role in antifungal innate immunity. Dectin-1 is a specific receptor for β-glucans. β-glucans are glucose polymers found in the cell walls of fungi, including the yeasts Saccharomyces cerevisiae and Candida albicans.
Dectin-2 binds to mannose carbohydrates, such as the mannose-capped lipoarabinomannan of mycobacteria and α-mannans found in Candida albicans.
Mincle recognizes a variety of exogenous and endogenous stimuli, such as mycobacteria, some fungi and necrotic cells.