InvivoGen provides an expanding collection of human and mouse cell lines in which specific genes are over-expressed or knocked out.
InvivoGen’s cell lines are reliable tools for:
- studying specific gene function(s)
- investigating cell signaling pathways and signal transduction
- screening agonists/antagonists of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), C-type lectin receptors (CLRs), cytosolic DNA sensors (CDSs), and aryl hydrocarbon receptor (AhR)
- measuring cytokine production
- validating antibody function
Most of InvivoGen's cell lines are engineered to stably express an inducible secreted reporter gene. We offer two reporter systems relying either on the secreted embryonic alkaline phosphatase (SEAP) or the Lucia luciferase.
The activity of these two reporter proteins is readily measurable in the cell culture supernatant using InvivoGen’s detection reagents.
Our cell lines are extensively tested for viability, biological activity and absence of mycoplasma to ensure strong and reproducible results. Moreover, we provide detailed handling and experimental procedures for all cell lines, thus minimizing the need for optimization or troubleshooting by the end-user.