When you can’t do it alone: TLR2 heterodimers and innate immunity
TLR2 (Toll-like receptor 2) is an important pattern recognition receptor (PRR) detecting a large spectrum of pathogen-associated molecular patterns (PAMPs) from bacteria, fungi, and parasites. An essential feature of TLR2 is its known ability to form functional heterodimers with TLR1 and TLR6 on the cell surface, which not only expands the range of PAMPs that it can recognize but potentially also diversifies the downstream signaling cascades that it triggers within a host. This may allow for considerable plasticity in TLR2-dependent recognition and signaling. InvivoGen provides a growing collection of engineered reporter cell lines and ligands that are designed for investigating TLR2 ligand specificity and signaling pathways.