Invivogen
Menu

InvivoGen’s Reviews

Innate Immunity / PRR / Inflammasome

NLRP3: a sophisticated drug target

NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryopyrin or NALP3) is the best described inflammasome sensor and an attractive drug target. NLRP3 assembles into a multiprotein inflammasome complex to induce the secretion of IL-1β/IL-18 and pyroptosis in response to infections and cellular damage. However, NLRP3 inflammasome functions can also be detrimental to the host, as its abberant or chronic activation is linked with pathologies such as type-2 diabetes, gouty arthritis, cardiovascular and Alzheimer’s diseases, and rare genetic disorders such as CAPS (cryopyrin-associated-periodic-syndrome). Fast-paced research now aims at filling the gaps in the comprehension of NLRP3 inflammasome activation and regulation to develop novel therapeutics.

Read more

Previous reviews

Innate Immunity / PRR / IFN response

Viral dsRNA Signaling Through TLRs and RLRs

Viral infections induce a strong innate immune response characterized by the rapid production of type I interferons (IFN α/β) leading to the inhibition of virus replication.

Innate Immunity / PRR

Agonistic and Antagonistic Effects of LPS on TLR4

Bacterial lipopolysaccharide (LPS) is the major structural component of the outer wall of all Gram-negative bacteria and a potent activator of the immune system.

Innate Immunity / Products / IFN response

RNA interference: Induction of the IFN Response

RNA interference (RNAi) has become a powerful tool to uncover gene function and is evolving as a new therapeutic modality.

Innate Immunity / PRR

TLR7 and TLR8: Key players in the antiviral response

TLR7 and TLR8 are phylogenetically and structurally related. TLR7 is predominantly expressed in lung, placenta, and spleen, while TLR8 is predominantly expressed in lung and peripheral blood leukocytes, in particular monocytes.

Products

RNA Interference

RNA interference (RNAi) is one of the most exciting discoveries of the past decade in functional genomics. RNAi is rapidly becoming an important method for analyzing gene functions in eukaryotes and holds promise for the development of therapeutic gene silencing.

Innate Immunity

Type I IFN Production and Signaling

The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and adaptive immune systems including antigen presentation and...

Innate Immunity / PRR / IFN response

Toll-Like Receptors and Viral Infection

Toll-like receptors (TLRs) are essential for the recognition of microbial pathogens. A subset of TLRs, TLR3, TLR7/8, and TLR9, is involved in antiviral responses by triggering the production of antiviral cytokines such as type I interferons (IFNs). TLR3 responds to double stranded RNA, a replication intermediary for many viruses. TLR7/8 recognize viral single-stranded RNAs, whereas TLR9...

Innate Immunity / PRR

TLR9 Recognition and Signaling: An Update

Toll-like receptor 9 (TLR9) recognizes unmethylated bacterial CpG DNA and initiates a signaling cascade leading to the production of proinflammatory cytokines.

Products

pCpGfree vitro, A New Family of CpG-free Plasmids

pCpGvitro is a new family of expression vectors completely devoid of CpG dinucleotides that are selectable in mammalian cells.

Innate Immunity / PRR

Toll-like Receptor 11

To date, ten mammalian Toll-like receptors (TLRs) have been identified. They recognize specific molecular patterns associated with microbial pathogens and induce the activation of host-defense genes.

Pages

Customer Service
& Technical Support
Contact us
Shopping cart is empty