NLR and Related Genes
NOD-Like Receptors (NLRs, also known as CATERPILLERs) constitute a family of intracellular pattern recognition receptors (PRRs) that recognize cytoplasmic pathogen-associated molecular patterns (PAMPs) and/or endogenous danger signal.
NLRs are comprised of three distinct functional domains: an N-terminal effector domain involved in signaling, a centrally located regulatory NOD domain, and C-terminal LRRs serving as a ligand-recognition domain. NLRs have been grouped into several subfamilies on the basis of their effector domains:
- CARD subfamily includes NODs and IPAF
- Pyrin (PYD) subfamily consists of the NALPs
- BIR subfamily comprises the NAIPs
InvivoGen provides a selection of NLR genes as well as numerous genes involved in the NLR pathways cloned in an expression plasmid.