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Inflammasome

Inflammasomes are large intracellular multiprotein complexes that play a central role in innate immunity. They detect and respond to a large range of pathogen-associated molecular patterns (PAMPs), including bacterial flagellin, and damage-associated molecular patterns (DAMPs), such as uric acid crystals.

 

Read our review on Inflammasome

 

Inflammasomes contain a member of the NOD-like receptor (NLR) family, such as NLRP3 and IPAF, by which they are defined. The NLR protein recruits the inflammasome-adaptor protein ASC, which in turn interacts with caspase-1 leading to its activation. Once activated, caspase-1 promotes the maturation of the proinflammatory cytokines interleukin (IL)-1β and IL-18.

Inflammasome activation is crucial for host defense to pathogens but recent studies have also found a role for the inflammasomes in the pathogenesis of several inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis and atherosclerosis.

 

Read our review on Inflammasome activation

 

To further understand how inflammasomes are activated, InvivoGen provides a number of molecules known as inflammasome inducers or inflammasome inhibitors, as well as several cell lines.

 

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