Immunotherapy aims at modulating the immune system to fight against diseases. Biological tools can be used to either strengthen natural immunity in the context of infectious diseases and cancers or dampen immune responses in the context of auto-immune diseases/inflammatory conditions.
Increasing knowledge of immune regulation mechanisms and technical advancements have allowed the move from broad to more precise therapeutic strategies.
InvivoGen is offering a large panel of immunotherapy-related products (reporter cell lines, clinically relevant monoclonal antibodies, PRR ligands, and fusion proteins) to help investigate:
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- Immune Checkpoints (ICs): Co-inhibitory or co-stimulatory molecules expressed at the surface of immune cells that act as gatekeepers of immune responses.
- Antibody-Drug Conjugates (ADCs): also known as Immune Stimulating Antibody Conjugates (ISACs). ADCs are engineered recombinant antibodies coupled to synthetic PRR ligands that potentiate immune responses by triggering the production of pro-inflammatory cytokines and chemokines.
- T-cell Activation & TCR Signaling: Cell-based reporter assays designed to investigate T cell receptor (TCR) signaling, antigen-specific T-cell activation, T-cell co-stimulation. These assays are suitable for screening new T-cell-targeting therapeutics, such as bispecific T-cell engagers.
- Vaccination: Formulation of specific antigens and adjuvants that induce adaptive protecting immune responses against pathogens causing diseases (prophylactic vaccines) or against established tumors (therapeutic vaccines).
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Examples of immunotherapies against cancer
