PRRs & Innate Immunity
Innate immunity is an evolutionarily conserved system that provides the body's first line of defense against invading microbial pathogens. Activation of pattern recognition receptors (PRRs) expressed by innate immune cells contributes to maintain homeostasis by regulating endogenous processes, such as inflammation and cell death.
PRR ligands belong to three major categories depending on their origin: pathogen-associated molecular patterns (PAMPs) are common to microbes but not to mammals; damage-associated molecular patterns (DAMPs) are molecules released by the host's own tissues (e.g. from dying cells); aryl hydrocarbon receptor ligands (AhR ligands) are ranging from toxic xenobiotics (e.g. dioxin) to dietary compounds derived from host or microbiota metabolism.
Upon agonist detection, PRRs trigger intra-cellular signaling pathways leading the expression of proteins involved in the immune response.
InvivoGen provides cutting-edge and comprehensive collections of tools to study PRRs and innate immunity, as well as useful resources such as mini-reviews and posters.