Explore host immune responses to microbial metabolites
Microbial metabolites provide important signals through which the immune system detects and responds to microorganisms. InvivoGen offers a growing collection of research tools to investigate two distinct pathways involved in these responses: the ALPK1-TIFA signaling and the MR1-MAIT axis.
The ALPK1-TIFA axis mediates the intracellular detection of bacterial ADP- and UDP-heptose, sugar metabolite associated with lipopolysaccharide (LPS) biosynthesis in Gram-negative bacteria. Upon activation, ALPK1 phosphorylates TIFA, promoting TIFA oligomerization and downstream NF-κB-dependent inflammatory signaling.
The MR1-MAIT axis enables immune recognition of small-molecule metabolites derived from the microbial riboflavin (Vitamin B2) biosynthesis pathway. These metabolites are presented by MR1 (MHC class I-related protein 1) and recognized by the semi-invariant T-cell receptor expressed by mucosal-associated invariant T (MAIT) cells, triggering MAIT TCR signaling and activation.
InvivoGen provides dedicated cellular and molecular tools to investigate each axis, from microbial metabolites and their recognition or presentation to downstream cellular responses.
Choose from our collection
ALPK1–TIFA signaling
- NF-κB-SEAP reporter HEK293 cell lines
- ALPK1 agonists and antagonists
- ALPK1 & TIFA genes
MR1–MAIT axis
- MR1-expressing HEK293 cells
- MAIT reporter Jurkat cells
- MAIT-activating ligand precursor 5-A-RU
- MR1 & MAIT TCR genes
Key features
- Lot-to-lot functionally validated research tools
- Cellular and molecular tools for pathway investigation
- Robust and reproducible cell-based models
- High-quality synthetic microbial metabolites
