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Inside this issue:
Mini-review: TLR7 & TLR8: fraternal twins
Species-driven TLR7 and TLR8 responses: Reporter cell lines, ligands and inhibitor.
Cytosolic sensing of intermediate metabolites of LPS: KO-ALPK1 and KO-TIFA Reporter cells and ADP-Heptose.
Preventing contamination of primary cell cultures: Primocin™
Toll-like receptors (TLRs) play a pivotal role in the initiation of anti-infectious immune responses. Distinct pathogen-associated molecular patterns (PAMPs) are recognized by different TLRs, at the cell surface or in endosomes. TLR7 and TLR8 are endosomal receptors that share structural homology and sense viral single stranded (ss) RNA as well as synthetic base analogs. However, there are functional differences between these two TLRs.
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