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The innate immune system is armed with a limited set of germline-encoded pattern recognition receptors (PRRs) capable of sensing a tremendous variety of potential pathogens. Among these PRRs, two phylogenetically and structurally highly related Toll-like receptors, TLR7 and TLR8, recognize the same ligand, single-stranded (ss) RNA. Upon stimulation, they both induce the NF-kB and IRF pathways via MyD88, activating multiple immune cells (e.g. T cells), thus bridging the innate and adaptive...
InvivoGen presents a new Insight Newsletter reviewing TLR7 and TLR8 reporter cells, designed to monitor the intertwined NF-κB and IRF responses of the two Toll-Like Receptors TLR7 and TLR8. Also, M5049 (aka Enpatoran), a novel TLR7- and TLR8-specific antagonist, was added to our growing library of TLR7/8 ligands.
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