At the heart of InvivoGen's culture is a commitment to providing life scientists with high-quality and reliable research tools.
InvivoGen at a Glance
InvivoGen is a biotechnology company specializing in research tools for innate and adaptive immunity, metabolic disease, cell biology, and molecular biology. Founded in 1977 in Toulouse, France, InvivoGen develops and manufactures reagents, reporter cell lines, PRR ligands, vaccine adjuvants, cytokines, antibodies, and other tools for life science research worldwide. The company operates from Europe, North America, and Asia, serves researchers in 80 countries, and its products have been cited in more than 75,000 scientific publications.
About 60% of InvivoGen’s employees are scientists, ranging from laboratory technicians to PhD researchers, who make up more than a quarter of the scientific team. Together, they design tools used by academic and industrial laboratories to study immune signaling pathways, screen compounds, and develop new therapies and vaccines.
Our History
From a University Research Lab to a Global Biotechnology Company
InvivoGen's origins go back to Cayla, a company founded in 1977 in Toulouse by Dr. Gérard Tiraby, a professor of microbiology at Université Toulouse III and one of Europe's early pioneers in applied biotechnology. In the 1970s, Dr. Tiraby developed the antibiotic Zeocin®, and in the early 1980s the company introduced Plasmocin®, an anti-mycoplasma agent still widely used to protect cell cultures. Cayla built its reputation on microbial fermentation and genetic engineering, developing research tools for academic and industrial laboratories.
In 1997, the company expanded internationally with the creation of InvivoGen in San Diego, California, which became its U.S. headquarters. Drawing on its expertise in microbiology, InvivoGen became the first company to commercialize Toll-like receptor (TLR) ligands in 2000 and has since built one of the most comprehensive ranges of products for innate immunity research. In 2014, InvivoGen opened its Asian hub in Hong Kong and adopted the InvivoGen name worldwide. Today, it serves researchers in 80 countries through its three regional offices and a network of international distributors.
Our products
InvivoGen's catalog includes more than 1,000 products, built on in-house expertise in microbiology, molecular biology, cell culture and chemistry.
PRR Ligands and Innate Immunity Tools
InvivoGen offers one of the largest collections of pattern recognition receptor (PRR) agonists and antagonists, including natural and synthetic ligands for TLR, NOD, STING, RIG-I, and inflammasome pathways. These reagents are used to study innate immune activation in infectious disease, inflammation, and vaccine research.
Reporter Cell Lines for Immunology and Metabolic Research
InvivoGen's reporter cell lines, including HEK-Blue™ and THP1-Dual™ cells, allow researchers to measure the activation of signaling pathways triggered by PRR agonists, cytokines, and incretins with a simple colorimetric or luminescent readout. They are widely used in compound screening and in bioassays for drug release testing, and InvivoGen uses them in its own quality control and R&D.
Vaccine Adjuvants and Immunotherapy Tools
InvivoGen supplies preclinical-grade vaccine adjuvants under its VacciGrade™ label, including alum and emulsions such as AddaVax™, as well as PRR ligand adjuvants such as MPLA, Poly(I:C), and CpG ODNs. These tools help researchers shape and study adaptive immune responses to antigens. For immuno-oncology, InvivoGen also offers immune checkpoint reporter cells, clinically relevant monoclonal antibodies, and fusion proteins.
Selection Antibiotics and Cell Culture Reagents
InvivoGen manufactures selection antibiotics such as Zeocin®, Puromycin and Blasticidin for generating stable cell lines, along with cell culture reagents such as Primocin™ and Plasmocin® to prevent and eliminate contamination, and MycoStrip™ kits for mycoplasma detection.
Recombinant Proteins, Antibodies, and Inhibitors
InvivoGen's molecular biology and chemistry teams develop recombinant cytokines, antibodies and small-molecule inhibitors for research in cancer, immunotherapy, inflammation, infectious disease, vaccine development, immunometabolism and metabolic diseases.
Quality control
Every InvivoGen product is manufactured and tested in-house under strict quality control standards.
Each lot is tested for purity, biological activity, and the absence of contaminants such as endotoxins and mycoplasma, ensuring batch-to-batch consistency. InvivoGen uses its own reporter cell lines to verify the biological activity of its products before release, including PRR ligands, cytokines, antibodies, and inhibitors.
Our services
Custom Cell Line Development and Screening
InvivoGen offers tailored services for academic research teams and biotech and pharmaceutical companies, including custom reporter cell line development, gene cloning, cytokine agonist and antagonist screening, and PRR compound screening. Every custom project follows the same quality control standards as InvivoGen's catalog products.
Technical Support
InvivoGen's technical support team is made up of scientists who help researchers choose the right products, design experiments, optimize assays, and troubleshoot results. Support is available by email, phone and video call from offices in France, the United States, and Hong Kong.
Worldwide Delivery
InvivoGen ships worldwide using logistics optimized for scientific materials. Every shipment follows strict preservation protocols, including temperature-controlled packaging and appropriate cooling for sensitive products such as cell lines. Its global distribution network ensures reagents arrive quickly and in perfect condition, ready for immediate use.