DNA Synthesis Inhibitors

InvivoGen provides DNA synthesis inhibitors. These products are FDA-approved for human treatment but are suitable for research purposes only.

- 5-Fluorouracil (5-FU) Thymidylate Synthase Inhibitor - Prodrug for fur, fcy::fur, upp and codA::upp genes
- Ganciclovir (GCV) DNA Synthesis Inhibitor - Prodrug for HSV1-tk and EHV4-tk genes

The prodrugs 5-fluorouracil and ganciclovir are relatively non-toxic compounds. Once administered, they are metabolized by their corresponding suicide genes into highly cytotoxic metabolites.

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