DNA Synthesis Inhibitors
InvivoGen provides DNA synthesis inhibitors. These products are FDA approved for human treatment but are suitable for research purposes only.
- 5-Fluorocytosine (5-FC) DNA Synthesis Inhibitor - Prodrug for codA, codA::upp, fcy and fcy::fur genes
- 5-Fluorouracil (5-FU) Thymidylate Synthase Inhibitor - Prodrug for fur, fcy::fur, upp and codA::upp genes
- Ganciclovir (GCV) DNA Synthesis Inhibitor - Prodrug for HSV1-tk and EHV4-tk genes
The prodrugs 5-fluorocytosine, 5-fluorouracil and ganciclovir are relatively non-toxic compounds. Once administered, they are metabolized by their corresponding suicide genes into a highly cytotoxic metabolites.