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Synthetic S. cerevisiae cytosine deaminase-uracil phosphoribosyl transferase fusion gene
Synthetic cytotoxic CD::UPRT fusion gene in expression plasmid
Suicide genes code for enzymes, such as cytosine deaminase (CD), that convert non-toxic compounds (prodrugs) into toxic products. CD converts cytosine and its analog, 5-fluorocytosine (5-FC), to uracil and 5-fluorouracil (5-FU) respectively.
5-FU is a toxic compound commonly used as anticancer drug.
To increase the efficiency of the CD/5-FC pair, InvivoGen has fused the gene encoding uracil phosphoribosyl transferase (UPRT) to the CD gene.
UPRT converts 5-FU to 5-FUMP, an irreversible inhibitor of thymidylate synthase.
CD::UPRT fusions are 100 times more efficient than the CD genes alone and provide greater bystander effect.Back to the top
Gene: CpG-free Fcy::fur
Description: Synthetic S. cerevisiae cytosine deaminase-uracil phosphoribosyl transferase fusion gene
33 CpG in native gene.Back to the top