Synthetic CpG-free Genes
Many non-mammalian genes are widely used as reporter or suicide genes in molecular and cellular studies.
However these genes are recognized as foreign DNA by the vertebrate host leading to a progressive decline of their expression.
To circumvent this limitation, InvivoGen has synthesized new alleles of these genes completely devoid of CpG dinucleotides.
These synthetic CpG-free genes display higher activity and lower immunogenicity than their wild-type counterparts.