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CpG-free Genes

Synthetic CpG-free Genes

Many non-mammalian genes are widely used as reporter or suicide genes in molecular and cellular studies.

However these genes are recognized as foreign DNA by the vertebrate host leading to a progressive decline of their expression.

To circumvent this limitation, InvivoGen has synthesized new alleles of these genes completely devoid of CpG dinucleotides.

These synthetic CpG-free genes display higher activity and lower immunogenicity than their wild-type counterparts.

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