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Ganciclovir (GCV)

Ganciclovir Unit size Cat. code Docs Qty Price
DNA synthesis inhibitor
250 mg
sud-gcv
+-
$172.00

Nucleoside analog for in vitro and in vivo cytotoxicity assays

Ganciclovir (GCV) is a guanosine analog used as a prodrug to obtain a suicide effect in cells transfected with the herpes virus thymidine kinase gene (HSV-tk).

HSVTK phosphorylates GCV to GCV-monophosphate which is further converted to GCV-diphosphate and GCV-triphosphate by host kinases. GCV-triphosphate causes premature DNA chain termination and apoptosis.

Ganciclovir is approved by the FDA for the treatment of cytomegalovirus (CMV) infections.

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Specifications

CAS number: 82410-32-0

Formula: C9H13N5O4

Molecular weight: 255.2

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Contents

  • 250 mg

room temperature GCV is shipped at room temperature.

store Store at -20°C.

stable GCV as a powder is stable for at least one year when properly stored.

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Citations

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