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DNA synthesis inhibitor
Nucleoside analog for in vitro and in vivo cytotoxicity assays
Ganciclovir (GCV) is a guanosine analog used as a prodrug to obtain a suicide effect in cells transfected with the herpes virus thymidine kinase gene (HSV-tk).
HSVTK phosphorylates GCV to GCV-monophosphate which is further converted to GCV-diphosphate and GCV-triphosphate by host kinases. GCV-triphosphate causes premature DNA chain termination and apoptosis.
Ganciclovir is approved by the FDA for the treatment of cytomegalovirus (CMV) infections.Back to the top
CAS number: 82410-32-0
Molecular weight: 255.2Back to the top
- 250 mg
GCV is shipped at room temperature.
Store at -20°C.
GCV as a powder is stable for at least one year when properly stored.Back to the top