U0126

MAPK Kinase Inhibitor - Autophagy Inhibitor - MEK1 and MEK2 Inhibitor

U0126 is a selective inhibitor of MAP kinase kinases, MEK1 and MEK2 [1].

It acts by inhibiting the kinase activity of MEK1/2 thus preventing the activation of MAP kinases p42 and p44 which are encoded by the erk2 and erk1 genes respectively.

MAPK p42/p44 are involved in the signaling cascade triggered by LPS and other ligands through stimulation of the TLRs [2,3,4].

U0126 inhibits MEK1 and MEK2, and thus ERK activation. U0126 can be used to study the role of ERK, a MAPK involved in the induction of autophagy.

References:

1. Favata MF. et al., 1998. J. Biol. Chem. 273:18623-32.
2. de Franco AL. et al., 1998. Prog Clin Biol Res. 397:119-36.
3. Rabehi L. et al., 2001. Infect Immun. 69:4590-9.
4. Rhee sH. et al., 2004. J Biol Chem. 279:25179-88.

Specifications

Working concentration: 10- 50 µM

CAS number: 109511-58-2

Synonym: 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene

Molecular weight: 380.5

Solubility: DMSO, 10 mg/ml

Purity: >99% (HPLC, TLC)

Contents

U0126 is provided as a solid.

• 5 mg

U0126 is shipped at room temperature.

Store at -20 ̊C.

Solid product is stable 1 year at -20°C