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MEK1 and MEK2 Inhibitor
MAPK Kinase Inhibitor - Autophagy Inhibitor - MEK1 and MEK2 Inhibitor
U0126 is a selective inhibitor of MAP kinase kinases, MEK1 and MEK2 .
It acts by inhibiting the kinase activity of MEK1/2 thus preventing the activation of MAP kinases p42 and p44 which are encoded by the erk2 and erk1 genes respectively.
MAPK p42/p44 are involved in the signaling cascade triggered by LPS and other ligands through stimulation of the TLRs [2,3,4].
U0126 inhibits MEK1 and MEK2, and thus ERK activation. U0126 can be used to study the role of ERK, a MAPK involved in the induction of autophagy.
1. Favata MF. et al., 1998. J. Biol. Chem. 273:18623-32.
2. de Franco AL. et al., 1998. Prog Clin Biol Res. 397:119-36.
3. Rabehi L. et al., 2001. Infect Immun. 69:4590-9.
4. Rhee sH. et al., 2004. J Biol Chem. 279:25179-88.
Working concentration: 10- 50 µM
CAS number: 109511-58-2
Molecular weight: 380.5
Solubility: DMSO, 10 mg/ml
Purity: >99% (HPLC, TLC)Back to the top
U0126 is provided as a solid.
- 5 mg
U0126 is shipped at room temperature.
Store at -20 ̊C.
Solid product is stable 1 year at -20°CBack to the top