FK506 Unit size Cat. code Docs Qty Price
Calcineurin inhibitor
10 mg

Calcineurin inhibitor

FK506 (Tacrolimus) is commonly used as an immunosuppressant to prevent the rejection of organ transplants.

Similarly to cyclosporin A (CsA), FK506 blocks the activation of calcineurin through the formation of complexes with immunophilins. FK506 binds to a different immunophilin than CsA, called FK506 binding protein (FKBP) 12 [1].

Further, it has been demonstrated that the FK506–FKBP complex suppresses the activation of the calcineurin-dependent NFAT pathway and calcineurin-independent activation pathway for JNK and p38 [2,3].



1. Powell JD & Zheng Y., 2006. Dissecting the mechanism of T-cell anergy with immunophilin ligands. Curr Opin Investig Drugs. 7(11):1002-7.
2. Matsuda S. et al., 2000. Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. EMBO Rep. 1(5):428-34.
3. Vafadari R. et al., 2012. Inhibitory Effect of Tacrolimus on p38 Mitogen-Activated Protein Kinase Signaling in Kidney Transplant Recipients Measured by Whole-Blood Phosphospecific Flow Cytometry. Transplantation. 93(12):1245-51.

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Synonym: Tacrolimus, FK-506

CAS number: 109581-93-3

Formula: C44H69NO12

Molecular weight: 822.03

Solubility: 100 mg/ml in DMSO

Working concentration: 1 - 100 nM

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FK506 is provided as a translucent film.

  • 10 mg FK506

FK506 is shipped at room temperature.

Store at -20 °C.

Solid product is stable for 2 years at -20 °C.

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fk506 chemical structure

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