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FK506 (Tacrolimus) is commonly used as an immunosuppressant to prevent the rejection of organ transplants.
Similarly to cyclosporin A (CsA), FK506 blocks the activation of calcineurin through the formation of complexes with immunophilins. FK506 binds to a different immunophilin than CsA, called FK506 binding protein (FKBP) 12 .
Further, it has been demonstrated that the FK506–FKBP complex suppresses the activation of the calcineurin-dependent NFAT pathway and calcineurin-independent activation pathway for JNK and p38 [2,3].
1. Powell JD & Zheng Y., 2006. Dissecting the mechanism of T-cell anergy with immunophilin ligands. Curr Opin Investig Drugs. 7(11):1002-7.
2. Matsuda S. et al., 2000. Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. EMBO Rep. 1(5):428-34.
3. Vafadari R. et al., 2012. Inhibitory Effect of Tacrolimus on p38 Mitogen-Activated Protein Kinase Signaling in Kidney Transplant Recipients Measured by Whole-Blood Phosphospecific Flow Cytometry. Transplantation. 93(12):1245-51.
Synonym: Tacrolimus, FK-506
CAS number: 109581-93-3
Molecular weight: 822.03
Solubility: 100 mg/ml in DMSO
Working concentration: 1 - 100 nMBack to the top
FK506 is provided as a translucent film.
- 10 mg FK506
FK506 is shipped at room temperature.
Store at -20 °C.
Solid product is stable for 2 years at -20 °C.Back to the top
Back to the top