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26S proteasome inhibitor - Autophagy activator
26S proteasome inhibitor
MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome.
This potent inhibitor is used as a tool for disrupting the proteasome-regulated degradation of intracellular proteins, such as IκB. Inhibition of IκB proteasomal degradation by MG-132 leads to the suppression of NF-κB activation .
Recent studies suggest that inhibition of the proteasome by MG-132 can induce autophagy by stabilizing Atg protein levels.
1. Lee DH, Goldberg AL., 1998. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 8(10):397-403.Back to the top
Working concentration: 0.2 - 20 µM.
CAS number: 133407-82-6.
Molecular weight: 475.62.
Solubility: 20 mg/ml in DMSO.Back to the top
- 5 mg MG-132 provided lyophilized
MG-132 is shipped at room temperature.
Store lyophilized product at -20°C.
Lyophilized product is stable for 1 year when properly stored.Back to the top