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Z-VAD-FMK

Z-VAD-FMK Unit size Cat. code Docs Qty Price
Caspase inhibitor
1 mg
tlrl-vad
+-
$150.00

Pan-Caspase inhibitor

Z-VAD-FMK is a cell-permeable pan-caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases [1].

The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability.

Z-VAD-FMK is used in apoptosis studies and also in inflammasome studies. It is a potent inhibitor of caspase-1 activation in NLRP3-induced cells [2].

Moreover, through the inhibition of caspases 3, 7 and 8, Beclin1 is stabilized and autophagy is promoted by Z-VAD-FMK.

 

1. Slee EA. et al., 1996. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J. 315 ( Pt 1):21-4.
2. Dostert C. et al., 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One. 4(8):e6510.

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Specifications

Working concentration: 10 μg/ml (20 μM)

Purity: 95%

Molecular weight: 467.5

Solubility: Soluble in DMSO (20 mM/10 mg/ml)

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Contents

Z-VAD-FMK is provided as a white solid.

  • 1 mg of Z-VAD-FMK (carbobenzoxy-valyl-alanyl-aspartyl-[O- methyl]- fluoromethylketone)

Z-VAD-FMK is shipped at room temperature.

Store at -20 ̊C.

Solid product is stable 1 year at -20°C.

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