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Torin 1 is a potent and selective ATP-competitive inhibitor of mTOR (mammalian target of rapamycin) kinase , the catalytic subunit of two functionally distinct complexes (mTORC1 and mTORC2) that coordinately promote cell growth, proliferation, and survival.
Unlike classical mTOR inhibitors such as rapamycin, Torin 1 is able to effectively block phosphorylation of mTORC1 and mTORC2 .
Torin 1 is an effective inducer of autophagy, as inhibition of mTOR mimics cellular starvation by blocking signals required for cell growth and proliferation [3, 4].
Interestingly, Torin 1 has also been shown to have cytotoxic and cytostatic effects in rapamycin-resistant cells .
Liu Q. et al., 2010. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective Mammalian Target of Rapamycin (mTOR) inhibitor for the treatment of cancer. Med Chem. 53(19):7146-55.
Thoreen CC. et al., 2009. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 284(12):8023‑32.
Jung CH. et al., 2010. mTOR regulation of autophagy. FEBS Lett. 584(7):1287-95.
Wang, R.C. et al., 2012. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 338(6109):956-9.
Park S. et al., 2016. Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells. BMB Rep. 49(1): 63‑68.
Zhou J. et al., 2013. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 23(4):508-23.
Working concentration: 250 nM (HeLa) , 1 µM (MEF). cf TDS.
Purity: >97% (HPLC)
Solubility: 2 mg/ml (3.29 mM) in DMSO
CAS number: 1222998-36-8
Molecular weight: 607.6
- The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
- 10 mg of Torin 1
Torin 1 is shipped at room temperature.
Store at -20 °C.
Upon resuspension, prepare aliquots of Torin 1 and store at -20 °C. Resuspended Torin 1 is stable for 6 months when properly stored.Back to the top