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LL-37: Antimicrobial peptide
LL-37, also known as hCAP18, is the C-terminal part of the only human cathelicidin identified to date called human cationic antimicrobial protein (hCAP).
LL-37 exhibits a variety of immunomodulatory functions such as bactericidal action, chemotaxis, activation of chemokine secretion and antisepsis effect .
The synthetic LL-37 peptide has been shown to suppress the inflammatory response induced by LPS and other TLR ligands .
1. Scott MG. et al., 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol. 169(7):3883-91.
2. Mookherjee N. et al., 2006. Modulation of theTLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol. 176(4):2455-64.
CAS number: 154947-66-7
Working concentration: 1 -50 µg/ml
Solubility: Water (1 mg/ml)
Amino acid sequence: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Molecular formula: C205H340N60O53
Molecular weight: 4493.37 g/mol
Purity: ≥ 95 % (UHPLC)Back to the top
LL-37 is provided lyophilized.
- 1 mg synthetic LL-37
- 1.5 ml endotoxin-free water
LL-37 is shipped at room temperature.
Store at -20°C.
Lyophilized product is stable 6 months when properly stored.Back to the top