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Bay11-7082

Bay11-7082 Unit size Cat. code Docs Qty Price
IκB-α inhibitor
10 mg
tlrl-b82
+-
$90.00

NLRP3 Inflammasome Inhibitor - IκB-α Inhibitor

Bay 11-7082 is an irreversible inhibitor of TNF-α-induced IκB-α phosphorylation resulting in the inactivation of NF-κB [1]. TNF-α-dependent effects of NF-κB are important for TLR expression and cytokine production [2,3]. Moreover Bay11-7082 selectively inhibit NLRP3 inflammasome activity in macrophages independent of their inhibitory effect on NF-κB activity [4].

 

1. Pierce JW. et al., 1997. Novel Inhibitors of Cytokine-induced Ikappa Balpha Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo.J. Biol. Chem., 272: 21096.
2. Phulwani NK. et al., 2008. TLR2 Expression in Astrocytes Is Induced by TNF-{alpha}- and NF-{kappa}B Dependent Pathways. J. Immunol. 181: 3841-3849.
3. Méndez-Samperio P. et al., 2008. Mycobacterium bovis Bacillus Calmette-Guérin Induces CCL5 Secretion via the Toll-Like Receptor 2-NF-{kappa}B and -Jun NTerminal Kinase Signaling Pathways. Clin. Vaccine Immunol.Clin. Vaccine Immunol. 15: 277-283.
4. Juliana C. et al, 2010. Anti-inflammatory Compounds Parthenolide and Bay11-7082 Are Direct Inhibitors of the Inflammasome. J. Biol Chem. 285(13): 9792–9802.

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Specifications

Working concentration: 1-10 μM

Purity: >99% (HPLC)

CAS number: 19542-67-7

Molecular weight: 207.3

Solubility: 25 mg/ml in DMSO and 15 mg/ml in ethanol

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Contents

BAY11-7082 is provided as a translucent film.

  • 10 mg BAY11-7082

room temperature BAY11-7082 is shipped at room temperature.

store Store at -20 °C.

stable Solid product is stable for 1 year at -20 °C.

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Citations

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