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Leptomycin B

Leptomycin B Unit size Cat. code Docs Qty Price
Nuclear export inhibitor
5 µg
tlrl-lep
+-
$236.00

Nuclear export inhibitor

Leptomycin B, an inhibitor of nuclear export, can be used to study nucleo-cytoplasmic translocation.

It has been demonstrated that Leptomycin B can cause the nuclear accumulation of proteins that shuttle between the cytosol and nucleus such as IRAK-1and NLRC5 [1, 2].

The cellular target of Leptomycin B has been identified as CRM1 (exportin 1), an evolutionarily conserved receptor for the nuclear export signal of proteins [3].

 

1. Liu G. et al., 2008. Interleukin-1 receptor-associated kinase (IRAK)-1-mediated NF-kB activation requires cytosolic and nuclear activity. FASEB J 22(7): 2285-96.
2. Benko S. et al., 2010. NLRC5 limits the activation of inflammatory pathways. J Immunol. 185(3):1681-91.
3. Kudo N. et al., 1999. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. PNAS. 96(16):9112-7.

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Specifications

CAS number: 87081-35-4

Formula: C33H48O6

Molecular weight: 540.73

Appearance: Clear, colorless solution

Working concentration: 50-100 nM

Quality control:

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Contents

  • 5 μg Leptomycin B is provided as 930 μL of a 10 μM solution (5.4 μg/ml in ethanol)

Note: This product is packaged under argon gas.

Leptomycin B is shipped at room temperature

Stored at -20˚C.

STABILITY WARNING: Leptomycin B in any quantity is unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of Leptomycin B, because rapid decomposition and loss of recoverable material will result.

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