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MCC950: NLRP3-inflammasome inhibitor
MCC950 is a potent and selective inhibitor of the NLRP3 (NOD-like receptor (NLR) pyrin domain-containing protein 3) inflammasome.
The NLRP3 inflammasome is an innate immune sensor that upon assembly activates caspase-1 and mediates the processing and release of IL‑1β.
MCC950 blocks the release of IL‑1β induced by NLRP3 activators, such as ATP, MSU and nigericin, by preventing oligomerization of the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing the a CARD) [1,2].
In research models of inflammation, such as cryopyrin associated periodic syndromes (CAPS) and myocardial infarction, it effectively inhibited NLRP3-induced IL-1β production [1-3]. Importantly, MCC950 does not inhibit the AIM2, NLRC4 or NLRP1 inflammasomes .
Coll RC. et al., 2015. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Med 21(3), 248-255.
Guo H. et al., 2015. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 21(7):677-87.
van Hout GP. et al., 2016. The selective NLRP3- inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. Eur Heart J. ehw247.
CAS number: 210826-40-7
Working concentration: 300 nM (121.34 ng/ml) to 10 μM (4.04 μg/ml) for cell culture assays
Solubility: DMSO (10 mg/ml)
Molecular weight: 404.48 g/mol
Purity: ≥98% (UHPLC)
- The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
- The inhibitory activity of the product has been validated using cellular assays.
- 10 mg MCC950
MCC950 is shipped at room temperature.
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