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Nigericin, sodium salt
NLRP3 Inflammasome Inducer
Nigericin is a microbial toxin derived from Streptomyces hygroscopicus. Nigericin acts as a potassium ionophore. The release of IL-1β in response to nigericin has been demonstrated to be NALP3-dependent . Similar to ATP, nigericin induces a net decrease in intracellular levels of potassium which is crucial for the activation of caspase-1 . Nigericin requires signaling through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release .
1. Mariathasan S. et al., 2006. Cryopyrin activates the inflammasome and ATP. Nature 440;228-32.
2. Locovei S. et al., 2007. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett. 581(3):483-8.
3. Pelegrin P, & Surprenant A., 2007. Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem. 282(4):2386-94.
Working concentration: 1 µM
CAS number: 28643-80-3
Synonym: Antibiotic K178, Polyetherin A
Molecular weight: 746.94
Endotoxin level: <0.125 EU/mg
Solubility: 5 mg/ml in ethanol
Nigericin is provided as a sodium salt and is available in two quantities:
• 10 mg : tlrl-nig
• 50 mg : tlrl-nig-5