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NLRP3 Inflammasome Inducer
NLRP3 Inflammasome Inducer - Nanoparticles of silica dioxide
SiO2 nanoparticles (Nano-SiO2) are single particles of silica dioxide, an inorganic metal oxide, with a diameter of less than 100 nm.
Nano-SiO2 was recently shown to trigger caspase-1 cleavage and IL-1β secretion in human macrophages and keratinocytes . The pro-inflammatory activity of nano-SiO2 is mediated by the NLRP3 inflammasome.
THP1 cells stably infected with shRNAs against caspase-1 or NLRP3 did not secrete IL-1β in response to nano-SiO2.
1. Yazdi AS. et al., 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. PNAS. 107(45):19449-54Back to the top
Working concentration: 10-200 µg/ml
CAS number: 7631-86-9
Linear formula: SiO2
Molecular weight: 60.08
Solubility: Not solubleBack to the top
- 10 mg Nano-SiO2 (nanoparticles of silicon dioxide)
Nano-SiO2 is shipped at room temperature.
Store at room temperature.Back to the top