Nano-SiO2

NLRP3 Inflammasome Inducer - Nanoparticles of silica dioxide

SiO2 nanoparticles (Nano-SiO₂) are single particles of silica dioxide, an inorganic metal oxide, with a diameter of less than 100 nm.

Nano-SiO₂ was recently shown to trigger caspase-1 cleavage and IL-1β secretion in human macrophages and keratinocytes [1]. The pro-inflammatory activity of nano-SiO₂ is mediated by the NLRP3 inflammasome.

THP1 cells stably infected with shRNAs against caspase-1 or NLRP3 did not secrete IL-1β in response to nano-SiO₂.

Reference:

1. Yazdi AS. et al., 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. PNAS. 107(45):19449-54

Specifications

Working concentration: 10-200 µg/ml

CAS number: 7631-86-9

Linear formula: SiO₂

Molecular weight: 60.08

Purity: ≥99%

Solubility: Not soluble

Contents

• 10 mg Nano-SiO2 (nanoparticles of silicon dioxide)

Nano-SiO2 is shipped at room temperature.

Store at room temperature.