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Curdlan

Curdlan Unit size Cat. code Docs Qty Price
Beta-1,3-glucan from Alcaligenes faecalis
1 g
tlrl-curd
+-
$98.00

Beta-1,3-glucan from Alcaligenes faecalis; Dectin-1 ligand

Curdlan is a high molecular weight linear polymer consisting of β-(1 -> 3)-linked glucose residues. Curdlan is produced as a water-insoluble polysaccharide by the soil bacterium, Alcaligenes faecalis.

Curdlan is recognized by the membrane bound Dectin-1 receptor leading to the CARD9-dependent activation of NF-κB and MAP kinases [1]. Furthermore, Dectin-1 signaling activates the NFAT transcription factor. Recent data suggest that Curdlan is also recognized by the cytosolic NLRP3 inflammasome complex which cooperates with Dectin-1 resulting in a robust activation of IL-1β–mediated inflammatory response [2].

 

1- Goodridge HS. et al., 2009. Beta-glucan recognition by the innate immune system. Immunol Rev. 230(1):38-50.
2- Kankkunen P., 2010. (1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages. J Immunol. 184(11):6335-42.

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Specifications

Specificity: Dectin-1 ligand
CAS number: 54724-00-4
Synonym: β-1,3-Glucan hydrate
Molecular Formula: (-C6H10O5-)

Quality control: The Dectin-1 activity is tested using HEK-Blue™ hDectin-1b and RAW-Blue™ cells. The presence of bacterial contamination (e.g. lipoproteins & endotoxins) is assessed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells. Curdlan induces TLR2 and TLR4 activity when used at concentrations higher than 100 ng/ml.

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Contents

1 g curdlan 

Curdlan is shipped at room temperature. Store at room temperature.

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Citations

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