InvivoGen offers a growing collection of CLR ligands
C-type lectin receptors (CLRs) are involved in fungal, bacterial and viral recognition, and play an important role in the modulation of the innate immune response. CLRs include the Dendritic cell-associated C-type lectin-1 (Dectin-1), Dectin-2, and macrophage-inducible C-type lectin (Mincle).
Dectin-1 is a specific receptor of β-glucans, which are glucose polymers found in the cell walls of fungi, including the yeasts Saccharomyces cerevisiae and Candida albicans.
Dectin-2 binds to mannose carbohydrates, such as the mannose-capped lipoarabinomannan of mycobacteria and α-mannans found in Candida albicans.
Mincle is a multi-task danger receptor that recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria.
Upon binding to their respective agonists, these receptors trigger signaling through the kinase Syk and the adaptors CARD9-Bcl10-Malt1. InvivoGen provides a Syk inhibitor, R406, which can be used to block this signaling pathway.
InvivoGen provides several CLR ligands
- Dectin-1 agonists – Curdlan, HKCA, Laminarin, Pustulan, Scleroglucan, WGP - Whole Glucan Particles, Zymosan and Zymosan Depleted
- Dectin-2 agonist – Furfurman
- Mincle agonists – β-GlcCer, HKMT and TDB
- CLR inhibitor - R406 (Syk inhibitor)
Key features of InvivoGen's products
- Each lot is functionally tested
- Guaranteed free of unwanted bacterial contaminants
