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Zymosan

Zymosan Unit size Cat. code Docs Qty Price
Cell wall preparation of S. cerevisiae
100 mg
tlrl-zyn
+-
$90.00

Cell wall preparation of S. cerevisiae

Zymosan, an insoluble preparation of cell wall from Saccharomyces cerevisiae, activates macrophages via TLR2.

TLR2 cooperates with TLR6 and CD14 in response to zymosan [1].

Zymosan is also recognized by Dectin-1, a phagocytic receptor expressed on macrophages and dendritic cells, which collaborates with TLR2 and TLR6 enhancing the immune responses triggered by the recognition of Zymosan by each receptor [2].

 

References

1. Ozinsky A. et al., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. PNAS. 97(25):13766-71.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med. 197(9):1107-17.

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Specifications

Specificity: TLR2 and Dectin-1 agonist

Working concentration: 1 - 10 μg/ml

CAS number: 58856-93-2

Endotoxin level: EndoFit™ (<0.001 EU/μg)

Solubility: Insoluble (resuspended zymosan results in a cloudy suspension)

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Contents

  • 100 mg Zymosan
  • 10 ml sterile endotoxin-free water

room temperature Zymosan is shipped at room temperature

store Stored at 4°C. Resuspended zymosan may be stored at 4°C for at least 6 months.

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Citations

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