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LTA-SA

LTA-SA Unit size Cat. code Docs Qty Price
Standard LTA from S. aureus
5 mg
tlrl-slta
+-
$124.00
Purified LTA-SA Unit size Cat. code Docs Qty Price
Purified LTA from S. aureus
5 mg
tlrl-pslta
+-
$171.00

Lipoteichoic acid from S. aureus

Lipoteichoic acid (LTA) is a major immunostimulatory component of Gram-positive bacteria. Like LPS, LTA is an amphiphile formed by a hydrophilic polyphosphate polymer linked to a neutral glycolipid.

LTA stimulates immune cells through TLR2 to produce TNF-α and other inflammatory cytokines. Recognition of LTA involves also LPS-binding protein (LBP) and CD14.

InvivoGen provides LTA from S. aureus (LTA-SA) and a purified form of LTA-SA, which is EndoFit™ (<0.001 EU/μg).

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Specifications

Specificity: TLR2 agonist

LTA-SA
Working concentration:
100 ng -1 μg/ml
Endotoxin level:
10 EU/mg

LTA-SA Purified
Working concentration:
1 ng -1 μg/ml
Endotoxin level:
EndoFit™

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Contents

LTA-SA

  • 5 mg S. aureus lipoteichoic acid (LTA-SA)

LTA-SA Purified

  • 5 mg LTA-SA Purified
  • 10 ml endotoxin-free water

room temperature LTA-SA is shipped at room temperature

store Stored at -20 ̊C. Upon resuspension, store LTA-SA at 4 ̊C for short term storage or at -20 ̊C for long storage.

Alert Avoid repeated freeze-thaw cycles.

stability Product is stable 1 month at 4̊C and 6 months at -20 ̊C when properly stored.

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Description

Lipoteichoic acid (LTA) is a major immunostimulatory component of Gram-positive bacteria. LTA shares many of the biochemical and physiological properties of the LPS of gram-negative bacteria. LTA is responsible for causing gram-positive sepsis. Like LPS, LTA is an amphiphile formed by a hydrophilic polyphosphate polymer linked to a neutral glycolipid. LTA stimulates immune cells through TLR2 to produce TNF-α and other inflammatory cytokines [1].

LTA-SA Purified contains 10 times less endotoxin according to the gel clot LAL Assay than the standard preparation. At concentrations ranging from 1 ng to 10 μg/ml, it highly activates TLR2 and no other TLRs including TLR4.

 

1. Schwandner R. et al., 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem, 274(25):17406-9.

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Citations

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