HKMT
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Cat.code:
tlrl-hkmt-1
- Documents
ABOUT
Heat-killed Mycobacterium tuberculosis
HKMT is a heat-killed preparation of the avirulent strain of Mycobacterium tuberculosis H37 Ra.
HKMT is sensed by Mincle which recognizes the mycobacterial cell wall glycolipid TDM. HKMT also possesses a large repertoire of TLR2 ligands, such as lipoproteins and lipomannan. Upon HKMT sensing, both Mincle and TLR2 lead to the activation of NF-κB.
References:
1. Ishikawa E. et al., 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. 206(13):2879-88.
2. Bhatt K & Salgame P., 2007. Host innate immune response to Mycobacterium tuberculosis. J Clin Immunol 27(4): 347–362.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
Mincle, TLR2
Mincle activity: 10 - 100 µg/ml
TLR2 activity: 100 ng - 10 µg/ml
10 mg/ml in water
Negative (tested using EndotoxDetect™ assay)
Cellular assays
Each lot is functionally tested and validated.
Lack of viability has been confirmed by microbiological testing
CONTENTS
Contents
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Product:HKMT
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Cat code:tlrl-hkmt-1
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Quantity:10 mg
1.5 ml endotoxin-free water
Heat-killed preparation of Mycobacterium tuberculosis H37Ra (HKMT) is provided lyophilized
Shipping & Storage
- Shipping method: Room temperature
- 4°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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