STING Reporter Cells

STING ligands trigger the production of type I IFNs and the induction of interferon stimulated genes (ISG) through interferon regulatory factors (IRFs).

In order to facilitate their study, InvivoGen has developed two types of stable reporter cells:

• Cells in which STING has been knocked out or knocked down
• Cells where the wild-type STING gene has been replaced by a STING variant (wild type STING knocked out, followed by a variant STING knocked-in)

These cells are either of human or mouse origin, and feature IRF-inducible secreted reporter proteins SEAP (secreted embryonic alkaline phosphatase) and/or Lucia luciferase as convenient read-outs.