STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS and ERIS) is essential for the TBK1-IRF3-dependent induction of IFN-β by microbial or self-DNA. It was recently found to act as a direct sensor of cyclic dinucleotides (CDNs). CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells acting as agonists of the innate immune response.
Several non-synonymous variants of STING have been described in the human population, as well as various induced mutants of the human and mouse STING genes. Studies have revealed that STING variation can affect CDN recognition and signal transduction.
InvivoGen provides most of the STING variants described, cloned and fully-sequenced into the expression plasmid pUNO1.