InvivoGen offers a collection of gene variants of STING, the key sensor of cytosolic nucleic acids
Choose from InvivoGen's extensive list of STING variants
STING (Stimulator of interferon genes), also known as TMEM173, MITA, MPYS, and ERIS, is essential for the TBK1-IRF3-dependent induction of IFN-β upon recognition of microbial or self-DNA. I nitially thought to serve solely as an adaptor protein for mediating signaling by cytosolic DNA sensors (CDS), STING was found to be a direct sensor of cyclic dinucleotides (CDNs). CDNs are important messengers in bacteria, affecting numerous responses of prokaryotic cells, but also in mammalian cells acting as agonists of the innate immune response.
Key features of InvivoGen's STING genes
- Fully sequenced genes from human and/or mouse
- Wildtype and gene variants available
- Selectable in both bacterial and mammalian cells
- Simple to subclone due to unique restriction sites
Several non-synonymous variants of STING have been described in the human population, as well as various induced mutants of the human and mouse STING genes. These gene variants (alleles and mutants) differ in their responsiveness to microbial CDNs leading to a loss or gain of STING functionality. Therefore, they represent a powerful tool to further understand STING biology and its impact on human health. STING and STING variants are highly implicated in many health disorders, such as infectious diseases, cancer, and autoimmunity, and is therefore considered a promising therapeutic target.
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