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pUNO1 bearing the human hSTING gene, G230A variant

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20 µg


Expression-ready ORF Clones

Human STING gene, G230A variant


STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs), such as c-di-GMP.
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.

Several non-synonymous variants of STING have been described in the human population. Studies have shown that STING variation can affect CDN recognition and signal transduction. A230 contains a single amino acid substitution G232A. G230 is located in the flexible loop that forms a lid above the c-di-GMP binding pocket. The G230A variant is able to respond to lower concentrations of CDNs due to a different binding to the ligand [1].

1. Yi G. et al., 2013. Single nucleotide polymorphisms of human STING can affect Innate immune response to cyclic dinucleotides. PLoS One 8(10):e77846.

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Human STING-A230 (pUNO1-hSTING-A230)

ORF size : 1140 bp
Subclone : BspEI - NheI

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pUNO1 Contents

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml


room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

stability Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Alert Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.

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