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pUNO1 bearing the human hSTING-A230 gene
STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs), such as c-di-GMP.
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.
Several non-synonymous variants of STING have been described in the human population. Studies have shown that STING variation can affect CDN recognition and signal transduction. A230 contains a single amino acid substitution G232A. G230 is located in the flexible loop that forms a lid above the c-di-GMP binding pocket. The G230A variant is able to respond to lower concentrations of CDNs due to a different binding to the ligand .
1. Yi G. et al., 2013. Single nucleotide polymorphisms of human STING can affect Innate immune response to cyclic dinucleotides. PLoS One 8(10):e77846.
Human STING-A230 (pUNO1-hSTING-A230)
ORF size : 1140 bp
Subclone : BspEI - NheI