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STING-M155

pUNO1-hSTING-M155 Unit size Cat. code Docs Qty Price
pUNO1 bearing the human STING gene, V155M variant
20 µg
puno1-hsting-m155
+-
$406.00

SAVI-associated V155M hSTING gene

STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the interferon (IFN) response to microbial or self DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs).

Several variants of STING have been described in the human population. The M155 (V155M) variant results in a gain-of- function mutation with the constitutive activation of STING and an upregulation of IFN production [1].

This mutation is associated with a chronic autoinflammatory disease, known as STING- associated vasculopathy with onset in infancy (SAVI) [2].

 

References:

1. Jeremiah N. et al., 2013. Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J Clin Invest. 124(12):5516-20.
2. Liu Y. et al., 2014. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 371(6):507-18.

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Specifications

Human STING-M155 (pUNO1-hSTING-M155)

ORF size : 1140 bp

Subclone : BspEI - NheI

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Contents

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C

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