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pUNO1 bearing the human STING lacking exon 7 isoform gene
STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs).
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.
hSTING-MRP (MITA-related protein), discovered and identified in HEK293T cells , is an alternatively spliced isoform of hSTING lacking exon 7 that acts as a dominant negative mutant of STING. It was recently reported to block STING-mediated IFN response while retaining the ability to active NF-kB .
1. Chen H. et al., 2014. An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs. J Immunol. 192(3):1162-70.
Human STING-MRP (pUNO1-hSTING-MRP)
ORF size : 852 bp
Subclone : BspEI - NheI