STING-Gt

Expression-ready ORF Clones

Mouse STING gene, I199N "Goldenticket (Gt)" variant

STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is an essential component of the innate immune response to microbial or self DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs) [1].

In mice, the Goldenticket (Gt) allele of STING was identified in an N-ethyl-N-nitrosourea (ENU)-induced mutagenesis screen for defects in the type I interferon (IFNs) response to Listeria monocytogenes. The Gt allele contains a T596A single-nucleotide substitution in exon 6, resulting in an I199N missense mutation in the STING protein [2]. 

The Gt allele is functionally null, with homozygous mice showing impaired IFN responses to Listeria monocytogenes and bacterial CDNs, and no detectable STING protein [2]. 

References:

1. Burdette DL. et al., 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 478:515–518.
2. Sauer JD. et al., 2011. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun. 79:688-694.