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STING-HAQ

pUNO1-hSTING-HAQ Unit size Cat. code Docs Qty Price
pUNO1 bearing the human STING gene, HAQ variant
20 µg
puno1-hsting-haq
+-
$406.00

Expression-ready ORF Clones

Human STING gene, R71H-G230A-R293Q variant

 

STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs).
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.

Several non-synonymous variants of STING have been described in the human population.
STING-HAQ has been identified as a common haplotype (∼20% of the human population and found in THP1 cells). HAQ contains three non-synonymous single nucleotide substitutions; R71H, G230A and R293Q. STING-HAQ expresses a STING protein that displays a reduced intrinsic IFN-β stimulatory activity [1, 2] but retains the ability to respond to metazoan and bacterial CDNs [2].

1. Jin L. et al., 2011. Identification and characterization of a loss-of-function human MPYS variant. Genes Immun. 12(4):263-9.
2. Yi G. et al., 2013. Single nucleotide polymorphisms of human STING can affect Innate immune response to cyclic dinucleotides. PLoS One 8(10):e77846.

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Specifications

Human STING-HAQ (pUNO1-hSTING-HAQ)

ORF size : 1140 bp
Subclone : BspEI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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