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Tumor-specific Promoters

Tumor Specific Promoters are active specifically in tumor cells, such as hepatocellular carcinoma, pancreatic cancer, prostate cancer, melanocytes...

Tumor Specific Promoters are available as native or composite promoter:
Native promoters,   also called minimal promoters,  consist of a single fragment from the   5’ region of a given gene. Each of  them comprises a core promoter and   its natural 5’UTR. In some cases,  the 5’UTR contains an intron.
Composite promoters combine promoter elements of different origins or were generated by  assembling a distal enhancer with a   minimal promoter of the same  origin.

In each pDRIVE, the promoter drives the expression of a reporter gene to   facilitate the evaluation of its activity. Three different reporter  genes  are available in two different backbones: LacZ reporter gene in  pDRIVE, secreted embryonic alkaline phosphatase (SEAP) or Lucia secreted luciferase reporter gene in pDRIVE5.

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