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pDRIVE-CEA

pDRIVE-hCEA Unit size Cat. code Docs Qty Price
pDRIVE bearing human CEA promoter - LacZ
20 µg
pdrive-hcea
+-
$433.00
pDRIVE5SEAP-hCEA Unit size Cat. code Docs Qty Price
pDRIVE bearing human CEA promoter - SEAP
20 µg
pdrive5s-hcea
+-
$433.00
pDRIVE5Lucia-hCEA Unit size Cat. code Docs Qty Price
pDRIVE bearing human CEA promoter - Lucia
20 µg
pdrive5lc-hcea
+-
$433.00

pDRIVE bearing human CEA promoter - LacZ, SEAP or Lucia
Gene Promoter: Carcinoembryonic Antigen
Specificity: Epithelial cancers
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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Contents

- Provided as 20 µg lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar).

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Description

The carcinoembryonic antigen (CEA) is a cell surface glycoprotein that is overexpressed in colorectal and other cancers of epithelial cell origin. The CEA promoter has been used to induce tumor-selective expression of exogenous genes in human colorectal [1], gastric [2] and lung cancers. In CEA producing cells, the CEA promoter has been shown to be as efficient as the SV40 enhancer/promoter in driving expression of therapeutic genes [1].

1. Cao G. et al. 1998. Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumorspecific gene expression. Int J Cancer 78:242-247.
2. Lan KH. et al. 1997. In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma. Cancer Res. 57(19):4279-84.
 

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Details

pDRIVE map

pDRIVE5-SEAP map

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