InvivoGen provides an extensive list of tools to study cytosolic DNA sensing
Double-stranded DNA (dsDNA) is a potent inducer of type I interferons (IFNs). Several sensors of cytosolic dsDNA have been identified, including cGAS, IFI-16, DDX41, and LRRFIP1, which trigger different signaling pathways in a cell-type-specific manner. AIM2 is another cytosolic DNA sensor, which upon activation forms an inflammasome leading to the secretion of IL-1β. The induction of type I IFNs by cytosolic DNA is mediated by the endoplasmic reticulum membrane protein STING (stimulator of IFN genes). To prevent excessive cytokine production, proteins such as the exonuclease TREX1 and the endonuclease DNase 2 degrade self-DNA inappropriately present in the cytosol. Deficiency in these proteins can cause autoimmunity.
InvivoGen provides a growing library of tools to study cytosolic DNA sensors (CDSs), regulators and STING signaling.
Choose from our comprehensive collection
- CDS reporter cells
- synthetic analogs of dsDNA as CDS ligands
- CDS inhibitors
- Fully sequenced CDS genes
Key features
- Each lot is functionally tested
- Guaranteed free of unwanted bacterial contaminants
➔ Find everything around STING and our comprehensive library of STING-related products
