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Immune checkpoint (IC)-expressing Cell Lines

IC-expressing Raji cells in an ADCC assay
IC-expressing Raji cells in an ADCC assay

InvivoGen provides an expanding collection of Raji cells that stably express immune checkpoints (ICs). These human B lymphocyte-derived cells were originally isolated from a Burkitt’s lymphoma patient and are characterized by a number of surface-expressed markers including the B cell receptor (BCR), CD19, and CD20. Additionally, they naturally express various levels of ICs such as CD27, CD70, CD80, PD-L1, and 4-1BBL.

These cells can be used as target cells for a number of applications including CAR-T cell toxicity assays as well as human mAb effector studies such as antibody-dependent cellular cytotoxicity (ADCC), either with peripheral blood mononuclear cells, natural killer cells, or T lymphocytes, including Jurkat-Lucia™ NFAT-CD16 cells developed by InvivoGen.

InvivoGen's Raji cell collection is an integral part of our in-house quality control for our anti-human biosimilar IC mAbs.

 

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