InvivoGen provides ligands that activate both NOD1 and NOD2 such as PGNs and M-TriDAP, a PGN degradation product.
NOD1 (CARD4) and NOD2 (CARD15) are two members of the growing family of Nod-like receptors (NLRs, also known as CATERPILLER), characterized by a nucleotide-oligomerization domain (NOD) and ligand-recognizing leucine-rich repeats.
NOD1 and NOD2 are involved in the recognition of peptidoglycan (PGN), major surface component of Gram-positive bacteria.
The functionality of these NOD1/NOD2 ligands is validated using HEK-Blue™ NOD1 and HEK-Blue™ NOD2 Cells.