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NOD1/NOD2 Agonist - MurNAc-L-Ala-gamma-D-Glu-mDAP - PGN-like molecule
MurNAc-L-Ala-γ-D-Glu-mDAP (M-TriDAP), also called DAP-containing muramyl tripeptide is a peptidoglycan (PGN) degradation product found mostly in Gram-negative bacteria.
M-TriDAP is recognized by the intracellular sensor NOD1 (CARD4) and to a lesser extend NOD2 (CARD15).
Recognition of M-TriDAP by NOD1/NOD2 induces a signaling cascade involving the serine/threonine RIP2 (RICK, CARDIAK) kinase which interacts with IKK leading to the activation of NF-κB and the production of inflammatory cytokines such as TNF-α and IL-6 . M-TriDAP induces the activation of NF-κB at similar levels to Tri-DAP .
Note: M-TriDAP is a mixture of MurNAc-L-Ala-γ-D-Glu-D- mDAP and MurNAc-L-Ala-γ-D-Glu-L-mDAP
1. Park JH. et al., 2007. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol. 178(4):2380-6.
2. Girardin SE. et al., 2003. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem. 278(43):41702-8.
Specificity: NOD1/NOD2 agonist
Working Concentration: 100 ng - 10 µg/ml
Molecular weight: 665.64
Synonym: N-acetyl-muramyl-L-Ala-γ-D-Glu-meso- diaminopimelic acidBack to the top
M-TriDAP is provided as a lyophilized powder.
- 1 mg M-TriDAP
- 1.5 ml endotoxin-free water
M-TriDAP is shipped at room temperature.
Store at -20°C.Back to the top