NOD-Like Receptors

NOD-Like Receptors (NLRs) constitute a family of intracellular pattern recognition receptors (PRRs), which contains more than 20 members in mammals.

Their primary role is to recognize cytoplasmic pathogen-associated molecular patterns (PAMPs) and/or endogenous danger signal, inducing immune responses.

NLRs are characterized by a tripartite-domain organization with a conserved nucleotide binding oligomerization domain (NOD) and leucine-rich repeats (LRRs).

InvivoGen offers a large set of tools to study the NLRs, in particular the NOD1 and NOD2 signaling pathways: NOD reporter cell lines, NOD ligands, and fully sequenced NLR and related genes.


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