NOD-Like Receptors - NLRs
NOD-Like Receptors (NLRs) constitute a family of intracellular pattern recognition receptors (PRRs), which contains more than 20 members in mammals.
Their primary role is to recognize cytoplasmic pathogen-associated molecular patterns (PAMPs) and/or endogenous danger signal, inducing immune responses.
NLRs are characterized by a tripartite-domain organization with a conserved nucleotide binding oligomerization domain (NOD) and leucine-rich repeats (LRRs).
InvivoGen offers a large set of tools to study the NLRs, in particular the NOD1 and NOD2 signaling pathways: NOD reporter cell lines, NOD ligands, shRNAs as NLR inhibitors, and fully sequenced NLR and related genes.