Choose from InvivoGen's extensive list of native or engineered TLR genes
To support your research, InvivoGen offers a variety of genes related to the Toll-like receptor (TLR) pathways. These genes can be provided in their native form, or modified by adding tags or creating dominant negative variants to facilitate diverse experimental applications.
Key features of InvivoGen's TLR genes
- Fully sequenced genes from various species (human, mouse, bovine, etc.)
- Selectable in both bacterial and mammalian cells
- Simple to subclone due to unique restriction sites
- Choice of native or engineered genes (GFP fusion proteins, tagged, TIR-less)
Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) that have evolved to play a vital role in the innate immune system. They are homologs of the Toll protein, found in Drosophila, and are essential for detecting and responding to pathogens.
TLRs identify highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs) and danger-associated molecular patterns (DAMPs), which are endogenous molecules released from damaged or dying cells. Upon recognizing these ligands, TLRs trigger various signaling pathways, ultimately leading to proinflammatory cytokines production, which are crucial for orchestrating an effective immune response.
TLRs are critical for both detecting microorganisms and sensing internal danger signals, thus maintaining immune surveillance and homeostasis. They are a key research focus for understanding immune mechanisms and finding new therapeutic strategies, such as vaccine adjuvants.
➔ Didn't find your gene of interest? Explore InvivoGen's growing collection of over 1,800 full-length sequenced genes from A - Z.