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TLR02-DN

pUNO1-hTLR02-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR2-DN gene
20 µg
puno1-htlr2-dn
+-
$406.00
pUNO1-mTLR02-DN Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR2-DN gene
20 µg
puno1-mtlr2-dn
+-
$406.00
pUNO1-hTLR02-DN-HA Unit size Cat. code Docs Qty Price
pUNO1 bearing the human TLR2-DN gene, with HA-tag
20 µg
puno1ha-htlr2-dn
+-
$406.00
pUNO1-mTLR02-DN-HA Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse TLR2-DN gene, with HA-tag
20 µg
puno1ha-mtlr2-dn
+-
$406.00

Expression-ready ORF Clones

Alias : TLR2, CD282

TLR2-DN (ΔTIR) : Dominant Negative TIR-less TLR2 gene

 

TLR2 is involved in the recognition of multiple products of Gram-positive bacteria, mycobacteria and yeast. TLR2 has been shown to confer responsiveness to the lipopeptides present in LPS preparations.
However, it seems that some types of LPS can activate TLR2 [1]. TLR2 is known to heterodimerize with other TLRs, a property believed to extend the range of PAMPs that TLR2 can recognize.
TLR2 cooperates with TLR6 in the response to peptidoglycan [2] and diacylated mycoplasmal lipopeptide, and associates with TLR1 to recognize triacylated lipopetides. Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14.
TLR2-DN is a TIR-less form of the TLR2 gene generated by deleting the TIR domain (429 bp). This truncated gene is still able to recognize its ligands but is unable to induce the signaling cascade.

 

1. Netea MG. et al. (2002). Trends Immunol, 23(3):135-9.

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Specifications

Human TLR2-DN (pUNO1-hTLR02-DN)

ORF size : 1926 bp
Subclone : AgeI - NheI

Mouse TLR2-DN (pUNO1-mTLR02-DN)

ORF size : 1920 bp
Subclone : AgeI - NheI

Human TLR2-DN-HA (pUNO1-hTLR02-DN-HA)

ORF size : 1959 bp
Subclone : AgeI - NheI

Mouse TLR2-DN-HA (pUNO1-mTLR02-DN-HA)

Subclone : AgeI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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