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Engineered Fc Regions Lucia-Tagged

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20 µg

  • About
  • Specifications
  • pFUSEN Contents
  • Details

Production of Lucia luciferase-tagged IgG1e2-Fc fusion protein

pFUSEN-Lucia-hG2Fc is a cloning plasmid for the generation of a Lucia luciferase-tagged engineered Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region fused to the N-terminus of a protein of interest.

Lucia luciferase is a secreted reporter protein with advantageous characteristics when associated with Fc-fusion proteins.

It possesses superior carrier ability for excellent secretion of the chimeric protein. It provides a simple means to screen for recombinant clones and it minimally affects the activity of the protein of interest.

Human IgG1e2-Fc contains mutations in the site of interaction of IgG1 with FcRn that enhance the plasma half-life by increasing the affinity of IgG1 for FcRn.

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Isotype: IgG1 human

Mutations: M252Y/S254T/T256E + H433K/N434F


  • Increased binding to neonatal FcR (FcRn)
  • Increased half-life

Selectable with Zeocin™ in E. coli and mammalian cells.
For transient or stable transfection.

These products are covered by a Limited Use License (See Terms and Conditions).

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pFUSEN Contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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