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Fc-Fusion

pFUSE-Fc, a family of plasmids for the construction of Fc-Fusion proteins

• Large choice of Fc regions from different species: human, mouse, rat and rabbit
• Fc regions without intron (pFUSE-Fc) or with introns (pINFUSE-Fc)
• Native Fc regions or engineered Fc regions with altered effector functions
• Fusion the Fc domain of an immunoglobulin to the C-terminus (pFUSE) or N-terminus (pFUSEN) of a target protein

pFUSE-Fc is a family of plasmids developed to facilitate the construction of Fc-Fusion proteins by fusing a sequence encoding a given protein to the Fc region of an immunoglobulin.
Fc-fusion proteins are molecules consisting of an immunoglobulin Fc domain fused genetically to a protein of interest, such as an extracellular domain of a receptor, ligand, enzyme, or peptide. The Fc domain comprises the CH2 and CH3 regions of the IgG heavy chain and the hinge region. Fusion to an Fc domain endows the hybrid protein with additional biological and biophysical properties.

Plasmid Cloning site / Gene Fc Region Isotypes Available
 C-terminal Fc fusions
pFUSE-Fc Cloning sites - Native
- No introns
- Human IgG1, 2, 3, 4
- Mouse IgG1, 2a, 2b, 3
- Rabbit IgG
- Rat IgG2b
pINFUSE-Fc Cloning sites - Native
- With introns
- Human IgG1, 2, 3, 4
- Mouse IgG2b
pFUSE-Fc engineered Cloning sites - Engineered
- No introns
- Human IgG1, 2, 4
- Mouse IgG1, 2a
pFUSE-Lucia-Fc Lucia secreted luciferase - Cloning sites - Native
- No introns
- Human IgG1
- Mouse IgG2a
pFUSE-SEAP-Fc SEAP - Native
- No introns
- Human IgG1, 2, 3, 4
- Mouse IgG2a, 2b, 3
- Rabbit IgG
- Rat IgG2b
 N-terminal Fc fusions
pFUSEN-Fc Cloning sites - Native
- No introns
- Human IgG1,2
- Mouse IgG2a
pFUSEN-Fc engineered Cloning sites - Engineered
- No introns
- Human IgG1
pFUSEN-Lucia-Fc Lucia secreted luciferase - Cloning sites - Native
- No introns
- Human IgG1, 2
- Mouse IgG2a
pFUSEN-Lucia-Fc engineered Lucia secreted luciferase - Cloning sites - Engineered
- No introns
- Human IgG1

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